I received the following very helpful email from Tony. Indeed this works well on Lion.
This is what I used on Snow Leopard:
./configure --disable-dependency-tracking CFLAGS='-arch x86_64 -arch i386 -arch ppc'
Since Lion doesn't support ppc, you can skip that safely there:
I only solved this recently, solving
https://rt.cpan.org/Ticket/Display.html?id=73371